Method
Method
Tier is a density, not a colour: the grading survives greyscale printing and colour-blind reading, and no hue in this publication carries evidential meaning. Red and pink are accents, one per surface, never mixed.
- T1 · In vitro / mechanism
- T2 · Animal result
- T3 · Small or narrow human data
- T4 · Human efficacy or safety, single programme
- T5 · Replicated human efficacy
Tier definitions
| Tier | Requires | Held by |
|---|---|---|
| T1 | In vitro only, or mechanism without a tissue result | Nothing in this field holds it |
| T2 | Animal result, no human protocol proposed | Bioengineered tooth germ (organ germ transplant) · Dental epithelial organoids · Tooth root organoids / whole-tooth reassociation |
| T3 | Small or single-centre human data, narrow endpoint | Pulp and dentine repair (DPSC/SHED grafts, small molecules) |
| T4 | Human efficacy or safety data, single programme | Anti-USAG-1 antibody (TRG-035) |
| T5 | Human efficacy, replicated by an independent group | Nothing in this field holds it |
What we read
Peer-reviewed papers, trial registry entries, regulatory filings, and clinical disclosures. Preprints are recorded and marked as such. Press releases are evidence of a claim, never of a result.
What we do not do
No primary research, no interviews, no predictions, no advice about anyone's treatment. We do not estimate arrival dates, and we delete them from our own text when we find them.
Cadence
Full pass monthly; every entry carries the date it was last verified against a source. Tiers move only on citable evidence, and the pass that moves them says so.
Corrections policy
Nothing here is edited silently. When we get something wrong, the old text stays visible with a line through it and the reason is stated. Superseded passes are kept in the pass archive, unchanged, so the record of what we believed, and when, is always inspectable.
Provenance
Every tier claim resolves to an entry in the keyed bibliography. No inline URLs, no unsourced grading. The full programme dataset is published as machine-readable JSON under CC BY 4.0.
A note on surfaces
This publication uses two reading surfaces: a parchment page for the standing record, and a dark lightbox for the current pass. All decorative texture lives in one clearly marked CSS block: a kill-switch. Removing it changes nothing about layout, colour, or content; the record reads identically flat.