Independent · non-commercial · evidence on tooth regeneration
Human dentition normally stops after the baby teeth and the permanent teeth. Several research programs claim it does not have to. Third Teeth tracks what those claims are based on: what was actually measured, in which model, and as of what date.
Supersedes the pass of 2026-10-05. Superseded passes are kept, never edited.
Ledger
Plate I
Analysis
A Fourth Military Medical University team separates two amelogenesis imperfecta genes on the eruption axis: FAM20A cases almost always fail eruption, FAM83H cases do so in under a third, and RUNX2 occupies FAM20A, not FAM83H, regulatory DNA.
The Hong Kong group that last year tested L803-mts in cell dishes now reports inflamed co-cultures and a rat pulp injury model: mineral density comparable to MTA, significantly lower mineral volume, and macrophages pushed toward an anti-inflammatory phenotype.
A Japanese narrative review comparing SHEDs and DPSCs for cell-based pulp therapy finds no winner: animal readouts split, human histology covers one re-traumatized tooth, and no SHED cell-based vital pulp therapy study exists.