Independent · non-commercial · evidence on tooth regeneration
Human dentition normally stops after the baby teeth and the permanent teeth. Several research programs claim it does not have to. Third Teeth tracks what those claims are based on: what was actually measured, in which model, and as of what date.
Supersedes the pass of 2026-07-28. Superseded passes are kept, never edited.
Ledger
Plate I
Analysis
A review from Central South University and colleagues organizes the evidence that mechanical forces, transduced through Piezo channels and YAP/TAZ, gate root morphogenesis, timing of tooth replacement, and jaw remodeling: mechanics is a design variable, not noise, for tooth engineering.
In LPS-induced rat pulpitis, a single dose of MSC small extracellular vesicles resolved inflammation and rebuilt reparative dentin to the same area as MTA; the mechanism, shown only in cell culture, runs through CD73-driven adenosine signaling.
A French group applies the layer-by-layer cell-accumulation coating to human dental pulp stem cells for the first time, showing fibronectin-gelatin nanofilms improve survival in thick 3D constructs and yield a larger, more stable odontoblast core beneath an ameloblast-like layer.