Ledger
The dated record
Every event that bears on a tier, in date order. A development stage is true only as of a stated date; entries are never silently edited.
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2009-08-03
Functional bioengineered tooth replacement in an adult mouse
- Ikeda E, Morita R, Nakao K, et al. (2009). Fully functional bioengineered tooth replacement as an organ replacement therapy. Proceedings of the National Academy of Sciences 106(32):13475-13480.
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2021-02-12
Anti-USAG-1 antibody rescues tooth agenesis in mouse models (Science Advances)
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2024-05-03
Phase I first-in-human study of TRG-035 announced and registered (Kitano Hospital)
- Kitano Hospital / Toregem BioPharma (2024). First-in-human Phase I study of TRG-035 (anti-USAG-1 antibody): trial announcement and registry record , single ascending dose, adult participants. Kitano Hospital trial announcement, 3 May 2024.
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2025-09-29
TRG-035 receives Japanese orphan drug designation for severe congenital partial anodontia
- AMED / Toregem BioPharma (2025). TRG-035 receives Japanese orphan drug designation for severe congenital partial anodontia. AMED record, 29 September 2025.
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2026-05-19
Sponsor reports Phase I dosing complete; Pre-Series C financing disclosed for Phase II
- Toregem BioPharma (2026). Pre-Series C financing and Phase II preparation disclosure; sponsor reports Phase I dosing complete. Company disclosure, 19 May 2026.