T2
Dental epithelial organoids
Academic laboratories (e.g. Hemeryck et al., KU Leuven / UHasselt) · component · Animal result
- T1
- T2
- T3
- T4
- T5
Status
Human dental epithelial organoids recreate enamel-forming developmental tissue. A powerful model of cell behaviour; the work sits at the organoid/model boundary, not at a replacement tooth.
What would change this assessment
Organoid-derived enamel tissue of native thickness and orientation, integrated in a living jaw.
Tier history
- 2022-02-26 T2 Human-tooth epithelial organoids established with a stemness phenotype and differentiation potential, including in vivo assessment; a developmental model, not a replacement tooth.
Sources on file
- Hemeryck L, Hermans F, Chappell J, et al. (2022). Organoids from human tooth showing epithelial stemness phenotype and differentiation potential. Cellular and Molecular Life Sciences 79(3):153. doi:10.1007/s00018-022-04183-8