T3
Pulp and dentine repair (DPSC/SHED grafts, small molecules)
Multiple academic groups (Xuan et al. autologous pulp stem cell trial; Sharpe lab GSK-3 antagonist work) · repair · Small or narrow human data
- T1
- T2
- T3
- T4
- T5
Status
This is where human data actually is: a randomized, controlled trial of autologous pulp stem cell grafts in immature permanent incisors (26 patients evaluated, 24-month imaging) reported continued root development and regenerated pulp. Tideglusib dentine repair is preclinical; cell-free scaffolds and biomimetic enamel remineralisation address surface lesions, not enamel regrowth. Clinically relevant regeneration, but categorically different from growing a whole tooth.
What would change this assessment
Controlled human evidence that repair extends beyond the pulp space , true enamel regrowth rather than surface remineralisation.
Tier history
- 2017-01-09 T2 Tideglusib (GSK-3 antagonist) promotes reparative dentine formation in a mouse tooth-injury model (Neves et al., Scientific Reports). Animal result.
- 2018-08-22 T3 Randomized trial of autologous deciduous-tooth pulp stem cell implantation in immature permanent incisors: 26 patients evaluated with 24-month imaging, regenerated pulp tissue with vessels and nerves (Xuan et al., Sci Transl Med). Narrow endpoint , inside an existing tooth.
Sources on file
- Xuan K, Li B, Guo H, et al. (2018). Deciduous autologous tooth stem cells regenerate dental pulp after implantation into injured teeth. Science Translational Medicine 10(455):eaaf3227. doi:10.1126/scitranslmed.aaf3227
- Neves VCM, Babb R, Chandrasekaran D, Sharpe PT (2017). Promotion of natural tooth repair by small molecule GSK3 antagonists. Scientific Reports 7:39654. doi:10.1038/srep39654