T2
Tooth root organoids / whole-tooth reassociation
Academic laboratories (e.g. Syed-Picard lab, University of Pittsburgh) · component · Animal result
- T1
- T2
- T3
- T4
- T5
Status
Root-like organization from human dental stem cells is encouraging. Eruption, crown formation, innervation, and periodontal integration are unresolved. A 2026 scaling study by Calabrese et al. finds that smaller root-organoid constructs lose the layered mineral pattern, pointing to a minimum cell mass for proper patterning.
What would change this assessment
Eruption, crown formation, innervation, and periodontal integration of an organoid-derived construct in an animal jaw.
Tier history
- 2024-05-01 T2 Self-assembled tooth root organoids from postnatal human dental stem cells organize dentin-, pulp-, cementum- and ligament-like tissue; includes in vivo assessment. Eruption, crown, innervation and integration unresolved.
Sources on file
- Calabrese TC, Rothermund K, Gabe CM, et al. (2024). Self-assembly of tooth root organoid from postnatal human dental stem cells. Tissue Engineering Part A 30(9-10):404-414. doi:10.1089/ten.TEA.2023.0219
- Calabrese TC, Rothermund K, Syed FNP, et al. (2026). Effects of size scaling on cellular dynamics and tissue patterning in tooth root organoids. Frontiers in Bioengineering and Biotechnology 14:1801110. doi:10.3389/fbioe.2026.1801110